Showing posts with label risk factors. Show all posts
Showing posts with label risk factors. Show all posts

Mesothelioma Risk Factors

The biggest and almost exclusively known risk factor for mesothelioma is exposure to asbestos. Those who have inhaled or ingested the toxic mineral are prime candidates for developing the disease. Even indirect exposure (known as secondary exposure) has been linked to cause mesothelioma in many instances.

Risks from Direct Exposure

Anyone who has encountered asbestos is at risk for developing mesothelioma. Asbestos and asbestos-containing products were commonly used in a wide variety of industries throughout most of the twentieth century. Some workers in those industries encountered the dangerous mineral on a daily basis, unknowingly exposing themselves to a substance that would eventually wreak havoc on their lungs.

Workers who may have encountered asbestos on the job include:

  • Shipyard workers
  • Insulators
  • Construction workers
  • Electricians
  • Plumbers
  • Pipefitters
  • Steamfitters
  • Welders
  • Railroad employees
  • Power plant employees
  • Chemical plant employees
  • Boilermakers
  • Auto mechanics
  • 9/11 first responders/emergency personnel
In addition to these professions, individuals who perform do-it-yourself projects at home where asbestos is present may be at risk for developing the disease. Such asbestos-containing building materials that were used in homes include attic and pipeline insulation, drywall and drywall glue, floor and ceiling tiles, "popcorn" ceilings, cements, shingles, and much more.

Risk from Secondary Exposure

In the past decade, more and more cases of secondary exposure to asbestos have come to light. Those subject to secondary exposure are often people who live in a household where someone else works with asbestos. These individuals usually inhale asbestos fibers brought home on the hair and clothes of other family members.

Many secondary exposure cases have been discovered in young people who sat on their father's or grandfather's lap when they came home from work. Other examples of secondary exposure have been found among those who lived near a factory that produced asbestos-containing products or near mines that harvested asbestos-laced vermiculite. While these individuals had no direct contact with the toxic mineral, the amount of asbestos dust in the air was enough to cause them to develop mesothelioma or another asbestos-related disease.

Smoking

Studies have shown that smoking does not cause mesothelioma. However, those that smoke and are exposed to asbestos have a much higher chance of developing the disease. As a matter of fact, some statistics show that smokers are as much as 90 percent more likely to develop mesothelioma after being exposed to asbestos. This is an important risk factor and one that is often overlooked by long-time smokers. In addition, those who have already developed asbestosis should avoid smoking at all costs, as the combination of the two significantly raises the risk of contracting mesothelioma.

Mesothelioma Causes


Mesothelioma is a highly aggressive cancer that is difficult to both diagnose and treat. Between 2,000 and 3,000 cases of malignant mesothelioma are diagnosed each year in America, and these figures are projected to increase throughout the next decade.

A significant amount of research has been conducted on potential mesothelioma causes (also known as mesothelioma etiology) and scientific discoveries continue to help medical professionals further understand how this cancer develops.

Causes of Mesothelioma Cancer

An overwhelming body of scientific and medical evidence has proven that the primary cause of malignant mesothelioma is exposure to asbestos. The exact method by which asbestos causes mesothelioma is still being researched, but medical professionals have a number of theories:

  • Asbestos causes irritation and inflammation of mesothelial cells, which results in irreversible scarring, cellular damage, and eventually cancer.
  • Asbestos fibers enter cells and disrupt the function of cellular structures that are essential for normal cell division, causing cellular changes that lead to cancer.
  • Asbestos causes the production of free radicals. These molecules damage DNA, and cause cells to mutate and become cancerous.
  • The presence of asbestos causes cells to produce oncoproteins. These molecules cause mesothelial cells to ignore normal cellular division restraints, and s can lead to the development of cancer.

The element that ties each theory together is the fact that asbestos results in cellular damage. This causes cells to lose control over normal cell cycles and results in uncontrollable division. Healthy cells follow cycles of cell division that ensure tissues do not grow and duplicate beyond normal conditions - in cancerous cells, these restraints are lost.

In cases of mesothelioma, the result of the cellular damage is that membranes in the affected location begin to thicken, and fluid builds up in the spaces between membrane layers. As cancer cells continue to divide and pile on top of one another, tumors begin to form. The uncontrolled division of cancer cells results in the impaired function of the body's organs and systems (primarily due to factors such as internal pressure caused by the growth of tumors, and the reduction of essential nutrients for organs), resulting in a number of symptoms.

Additional Risk Factors

Other risk factors that may cause malignant mesothelioma include:

  • Radiation: Some mesothelioma patients with no traceable history of asbestos exposure do share a history of radiation exposure. Around 45 cases of mesothelioma following radiation therapy have been reported and discussed in medical literature.
  • Nonasbestos Mineral Fibers: A few nonasbestos mineral fibers have been linked to malignant mesothelioma, such as erionite and taconite.
  • Simian Virus 40: Originating in the rhesus monkey and contaminating millions of polio vaccines administered in the 1950s and ’60s, simian virus 40 has been linked to malignant mesothelioma and several other malignancies.

Additional risk factors that are not as well-researched in medical literature include chronic inflammation, chest injuries, genetics and organic chemicals.

It should be noted that cancer doctors and research scientists know that smoking does not cause mesothelioma, but it can aggravate other asbestos-related conditions (such as asbestosis) and compromises the body’s ability to fight the biological effects of asbestos fibers. Additionally, asbestos exposure and smoking has a synergistic affect that can increase a person's risk of developing lung cancer by as much as 84 times or more. For this reason, those who have been exposed to asbestos are highly advised not to smoke.